Drugs Associated with the Syndrome of Inappropriate Antidiuretic Hormone (SIADH) Secretion

 

Clinical features of drug-induced SIADH:

(1) absence of SIADH prior to drug exposure

(2) development of SIADH after starting the drug

(3) disappearance of the SIADH after drug discontinuation

(4) exclusion of other causes of SIADH

(5) recurrence of the SIADH upon re-exposure to the implicated drug

 

Since many drugs are associated with SIADH, it is important to consider all medications that the patient is taking.

 

Classes of drugs associated with SIADH:

(1) selective serotonin reuptake inhibitors (SSRI)

(2) tricyclic antidepressants

(3) other antidepressants

(4) antipsychotic agents

(5) chemotherapeutic agents

(6) antiepileptic drugs

(7) oral hypoglycemic agents

(8) angiotensin converting enzyme inhibitors (ACE inhibitors)

(9) thiazide diuretics

 

Drugs associated with SIADH include:

amantadine

aminoglutethimide

amiodarone

amitryptiline

amoxapine

azithromycin

bupropion

carbamazepine

chlorambucil

chlorpromazine

chlorpropamide

cisplatin

citalopram

clomipramine

clonidine

clozapine

cyclophosphamide

desipramine

diclofenac

docetaxel

doxepin

enalapril

etoposdie

fentanyl

fluoxetine

fluphenazine

fluvoxamine

haloperidol

ibuprofen

ifosfamide

imipramine

L-dopamine

levamisole

lisinopril

lorazepam

melphalan

methyldopa

mirtazapine

MMDA (Ecstasy)

nortriptyline

omeprazole

oxcarbazepine

paroxetine

phenlzine

pimozide

propafenone

quinpristin-dalfopristin

ramipril

rifabutin

risperidone

sertraline

theophylline

thiazide diuretics

thioridazine

thiotepa

thiothixene

tolbutamide

trazodone

trifluoperazine

trihexyphenidyl

valproic acid

venlafaxine

vinblastine

vincristine

vinorelbine