Xerostomia (dry mouth) may occur as a result of one or more conditions. A person may experience the sensation of oral dryness while having adequate saliva.


Drugs associated with decreased salivation:

(1) amphetamines and other sympathomimetic agents

(2) atropine and other anticholinergic agents

(3) antihistamines

(4) antineoplastic agents

(5) protease inhibitors for HIV therapy

(6) didanosine

(7) levodopa

(8) omeprazole

(9) selective serotonin reuptake inhibitors

(10) tramadol

(11) tricyclic antidepressants

(12) benzodiazepines

(13) antipsychotic agents

(14) beta-blockers


Risk factors for drug-induced xerostomia:

(1) multiple medications with additive effects (especially in the elderly)

(2) starting or increasing the dose of a drug


Xerostomia associated with destruction of salivary gland tissue:

(1) autoimmune disease with chronic sialadenitis (Sjogren's, other)

(2) bacterial or viral infection

(3) radiation of the head and neck

(4) obstruction of salivary ducts


Other conditions associated with a sensation of dry mouth:

(1) anxiety or depression

(2) mouth breathing

(3) dehydration


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