Therapy with certain drugs may be associated with leg edema.
Drugs associated with leg edema:
(1) antihypertensive drugs
(2) hormones: corticosteroids, estrogen, progesterone, oral contraceptives or testosterone
(3) nonsteroidal anti-inflammatory drugs (NSAIDS)
(4) pioglitazone or rosiglitazone
(5) monamine oxidase inhibitors (MAOI)
(6) gabapentin
(7) pregabalin
Antihypertensive drugs that can cause edema include:
(1) calcium channel blockers (amlodipine, other)
(2) beta blockers
(3) clonidine
(4) hydralazine
(5) minoxidil
(6) methyldopa
