A number of drugs may be associated with a rosacea-like dermatitis.

Drugs associated with a rosaceiform dermatitis:

(1) topical corticosteroids

(2) topical tacrolimus, pimecrolimus

(3) epidermal growth factor receptor (EGFR) inhibitor (cetuximab, panitumumab)

(4) EGFR tyrosine kinase inhibitors (erlotinib, gefitinib, lapatinib)

(5) B vitamins (pyridoxine, niacin, etc)

(6) vasodilators (calcium channel blockers, other)


Mechanisms may include:

(1) contact allergy

(2) vasodilation

(3) stimulation of Demodex

(4) inflammatory response

(5) photosensitvity



(1) The onset or worsening of rosacea after starting a medication.

(2) Improvement after discontinuation of the implicated drug.

(3) Relapse after restarting implicated drug.

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