A number of drugs may be associated with a rosacea-like dermatitis.
Drugs associated with a rosaceiform dermatitis:
(1) topical corticosteroids
(2) topical tacrolimus, pimecrolimus
(3) epidermal growth factor receptor (EGFR) inhibitor (cetuximab, panitumumab)
(4) EGFR tyrosine kinase inhibitors (erlotinib, gefitinib, lapatinib)
(5) B vitamins (pyridoxine, niacin, etc)
(6) vasodilators (calcium channel blockers, other)
Mechanisms may include:
(1) contact allergy
(2) vasodilation
(3) stimulation of Demodex
(4) inflammatory response
(5) photosensitvity
Features:
(1) The onset or worsening of rosacea after starting a medication.
(2) Improvement after discontinuation of the implicated drug.
(3) Relapse after restarting implicated drug.
