Begaud et al reported a scoring system to evaluate adverse drug effects. This was modified by Beaugerie and Pardi for drug-induced colitis.
Sections:
(1) causality
(2) chronology
Parameters for chronology:
(1) time between drug initiation and onset of diarrhea
(2) evolution of diarrhea and resolution after drug withdrawal
(3) recurrence of diarrhea on rechallenge
Time to Onset
Evolution and Resolution
Recurrence on Rechallange
Chronology
suggestive
R+ (positive)
Ch3
R0 (not done or cannot assess)
R- (negative)
Ch1
compatible
R+
R0
Ch2
R-
not compatible
Ch0
nonconclusive
nonsuggestive
Ch0 = ruled-out
Ch1 = doubtful
Ch2 = plausible
Ch3 = probable
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Specialty: Gastroenterology
