Drug-Induced Liver Injury Diagnostic Scale

Is the patient being evaluated for possible drug-induced liver injury?

Gender of patient

Is this the first exposure of the patient to the drug?

Has the implicated drug been well-associated with liver injury in the scientific literature?

Number of years that the implicated drug has been marketed

Is the drug known to accumulate in the body where it can persist for a long period of time?

Date of first intake of drug in recent exposure (MM/DD/YY)

Date of initial clinical and/or laboratory finding of liver disease (MM/DD/YY)

Was the drug stopped prior to the onset of liver-related findings?

Number of days between drug stoppage and onset of liver manifestations

Number of months after drug stopped before normalization of laboratory values occurred

Has the patient been rechallenged to the implicated drug after an interval of nonexposure?

Did the patient show an increase in liver function tests more than 2 times the upper limit of normal after the re-exposure?

Type of liver injury

Viral hepatitis

Alcoholic liver disease

Biliary tract obstruction

Pre-existing liver disease

Acute hypotension

Pregnancy

Does the patient have a skin rash?

Does the patient have fever?

Does the patient have arthralgias?

Does the patient have anemia?

Does the patient have thrombocytopenia?

Does the patient have granulocytopenia?

Percent eosinophils in white blood cell differential (enter from 0 to 100)