The Drug-Induced Liver Injury Network (DILIN) used a number of findings to grade the severity of a drug-induced liver injury (DILI).
Patient selection: drug-induced liver injury
Parameters:
(1) serum ALT
(2) serum alkaline phosphatase
(3) serum total bilirubin
(4) INR
(5) hospital stay
(6) hepatic failure (encephalopathy, ascites or INR >= 1.5)
(7) other organ failure related to event
(8) liver transplant because of DILI
(9) death because of DILI
Findings
Code
liver transplant and/or death
A
hepatic failure and/or other organ failure
B
hospitalized or hospital stay prolonged because of DILI
C
serum total bilirubin >= 2.5 mg/dL
D
INR >= 1.5
E
serum ALT and/or serum alkaline phosphatase elevated
F
Pattern
Grade
Term
5
“fatal”
F and D and B
4
severe
(F or D or E) and C
3
moderate to severe
F and (D or E)
2
moderate
1
mild
Symptom designation: asymptomatic (A) or symptomatic (S)
Symptoms:
(1) fatigue
(2) nausea
(3) vomiting
(4) right upper quadrant pain
(5) itching
(6) skin rash
(7) jaundice
(8) weakness
(9) anorexia
(10) weight loss
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Purpose: To determine the severity of drug-induced liver injury (DILI) using the criteria of the DILIN.
Specialty: Gastroenterology, Pharmacology, clinical
Objective: severity, prognosis, stage
ICD-10: K71,
