A patient receiving high dose, chemoreductive chemotherapy may develop hyperammonemia.
Features of chemotherapy-induced hyperammonemia:
(1) normal mental status and plasma ammonia levels prior to chemotherapy
(2) high dose chemotherapy administered
(3) onset of altered mental status with lethargy and confusion, often with some degree of cerebral edema on imaging studies
(4) elevated plasma ammonia level
(5) exclusion of other causes of hyperammonemia (including liver disease and multiple myeloma)
If the person survives the episode then the ammonia and symptoms should return to normal.
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Purpose: To evaluate a patient for hyperammonemia (HA) following high dose chemotherapy.
Specialty: Hematology Oncology, Endocrinology, Pharmacology, clinical
Objective: response to therapy, adverse effects