Aronson and Ferner reported the DoTS classification scheme for adverse drug reactions. The authors are from Radcliffe Infirmary and City Hospital Birmingham.
Parameters:
(1) dose dependency (Do)
(2) timing dependence (T)
(3) susceptibility (S)
Dosing dependence:
(1) overdose (supratherapeutic toxic effects)
(2) standard therapeutic dose (collateral effect)
(3) subtherapeutic dose (hypersusceptibility)
Timing dependent reactions:
(1) reaction to rapid administration
(2) first dose reaction
(3) early reaction (then abate)
(4) intermediate reaction (some delay)
(5) late reaction
(6) delayed reaction
Susceptibility:
(1) genetic factor
(2) age
(3) sex
(4) altered physiology
(5) exogenous factor (includes drug iinteraction)
(6) disease (renal or other organ failure)
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