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Rhogam Dosage in Massive Fetomaternal Hemorrhage

Purpose:

To determine the dose of Rhogam required for an Rh-negative whoman with a fetal maternal hemorrhage from an Rh-positive fetus.

Specialty:

Nephrology, Urology, Obstetrics & Gynecology, Pedatrics, Genetics
Clinical Laboratory

Objective:

dosage calculations, dosage adjustments

ICD-10:

P50.4

Description:

Since one 300 µg dose of RhIG will protect against a transplacental hemorrhage of 30 mL of Rh-positive fetal blood, the volume of fetal blood should be divided by 30 to determine the number of doses required. Calculating the volume of fetal blood in the maternal circulation is done by the Kleihauer-Betke procedure.

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