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Dosing Mesna as a Urothelial Protectant in a Patient Receiving Standard Dose Ifosfamide

Specialty:

Hematology Oncology
Clinical Pharmacology & Toxicology

Objective:

ICD-10:

Description:

Mesna (sodium-2-mercapto-ethane sulfonate) can prevent toxicity of ifosfamide and cyclophosphamide to the genitourinary tract if given before and after the chemotherapeutic agent is given. It provides free thiols which protect the urothelium from the alkylating metabolites of ifosphamide.

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