The dose of an enteric-coated pancrealipase preparation depends on the age of the patient and the dietary fat load. Usually an initial dose is selected and then this is titrated until the optimum dose is determined.
Age Group
Dose per Meal
Typical Dose Range
1 to 4 years
1,000 units lipase per kg body weight
16,000 - 24,000 units
5 -12 years
500 to 2,500 units lipase per kg body weight
24,000 - 40,000 units
>= 13 years
500 to 2,500 units lipase per kg body weight
40,000 - 64,000 units
Age Group
Dose per Snack
Typical Dose Range
1 to 4 years
50 - 66% of meal dose
8,000 - 16,000 units
5 -12 years
33 - 60% of meal dose
8,000 - 24,000 units
>= 13 years
40% of meal dose
16,000 - 24,000 units
Alternatively, a patient can be dosed based on dietary fat intake. Patients with cystic fibrosis require 500 to 4,000 (usually 1,800-2,000)units of lipase per gram dietary fat per day. Doses above 4,000 units per gram of dietary fat should be avoided to prevent overdosing.
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