Extravasation of doxorubicin from an intravenous infusion can cause serious soft tissue injury. Prompt infusion of dexrazoxane can reduce the severity of the damage.
Brand name for dexrazoxane: Totect in USA, Savene in EU
Patient selection: A patient with an extravasation of doxorubicin
Doses of dexrazoxane: given intravenously 3 days in a row
Day
Dose
1
MIN(2000 mg, 1000 mg per square meter BSA)
2
MIN(2000 mg, 1000 mg per square meter BSA)
3
MIN(1000 mg, 500 mg per square meter BSA)
Dosage reduction for renal failure: Reduce the dose by 50% if the creatinine clearance is < 40 mL per minute.
Timing of the first infusion: as soon as possible after the onset; it should be no more than 6 hours after the event.
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