Inada and Inagaki reported dose equivalence for long-acting injectable antipsychotic agents in Japan. The authors are from Seiwa Hospital and Aoyama Gakuin University in Japan.
Drug
Daily Oral Dose in mg
Long-Acting Formulation
Long-Acting Dose in mg
Haloperidol
2 mg/day
Haloperidol Decanoate (HP-D)
30 mg/4 weeks
Fluphenazine
2 mg/day
Fluphenazine Decanoate (FD)
15 mg/4 weeks
Risperidone
1 mg/day
Risperidone Long-Acting Injection (PAL-P)
10 mg/2 weeks
Paliperidone
1.5 mg/day
Paliperidone Palmitate (PAL-P)
18.75/4 weeks
where:
Oral Antipsychotic Agent
Equivalent Oral Dose
Chlorpromazine
100 mg
Haloperidol
2 mg
Fluphenazine
2 mg
Risperidone
1 mg
Paliperidone
1.5 mg
multiple of the equivalent dose =
= (actual dose) / (equivalent dose)
To convert between formualtions:
dose for new drug =
= (multiple of the equivalent dose for previous drug) * (equivalent dose for new drug)
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