Inada and Inagaki reported dose equivalence for drugs used as anxiolytics, sedatives and hypnotics in Japan. The authors are from Seiwa Hospital and Aoyama Gakuin University in Japan.
|
Drug |
Equivalent Dose |
|
alprazolam |
0.8 |
|
bromazepam |
2.5 |
|
chlordiazepoxide |
10 |
|
clobazam |
10 |
|
clonazepam |
0.25 |
|
clorazepate |
7.5 |
|
clotiazepam |
10 |
|
cloxazolam |
1.5 |
|
diazepam |
5 |
|
etizolam |
1.5 |
|
fludiazepam |
0.5 |
|
flutazolam |
15 |
|
flutoprazepam |
1.67 |
|
loflazepate |
1.67 |
|
lorazepam |
1.2 |
|
medazepam |
10 |
|
mexazolam |
1.67 |
|
oxazepam |
15 |
|
oxazolam |
20 |
|
prazepam |
12.5 |
|
tandospirone |
25 |
|
tofisopam |
125 |
|
Drug |
Equivalent Dose |
|
amobarbital |
50 |
|
barbital |
75 |
|
bromvalerylurea |
500 |
|
brotizolam |
0.25 |
|
butoctamide |
500 |
|
chloral hydrate |
250 |
|
estazolam |
2 |
|
eszopiclone |
2.5 |
|
flunitrazepam |
1 |
|
flurazepam |
15 |
|
haloxazolam |
5 |
|
lormetazepam |
1 |
|
nimetazepam |
5 |
|
nitrazepam |
5 |
|
Passiflora extract |
100 |
|
pentobarbital |
50 |
|
phenobarbital |
15 |
|
quazepam |
15 |
|
rilmazafone |
2 |
|
secobarbital |
50 |
|
triazolam |
0.25 |
|
zolpidem |
10 |
|
zopiclone |
7.5 |
where:
• Butoctamide is no longer available in Japan.
multiple of the equivalent dose =
= (actual dose) / (equivalent dose)
To convert to another drug in the table:
dose for new drug =
= (multiple of the equivalent dose for previous drug) * (equivalent dose for new drug)
Specialty: Pharmacology, clinical, Psychiatry
