Dose dumping refers to the sudden administration of an amount of drug meant to be slowly delivered over a much longer period of time.


Situations that can lead to dose dumping:

(1) crushing of time release or slow release tablet or capsule

(2) administration of a time-release medication with a food that enhances drug release

(3) rapid infusion due to an injection pump error


Risk factors for serious toxicity as a result:

(1) high drug dose

(2) therapy naïve patient

(3) factors that reduce drug metabolism or excretion

(3a) bypass of first pass metabolism

(3b) discontinuation of drug that enhances metabolism

(3c) failure affecting primary excretory organ


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