Kcentra (Prothrombin Complex Concentrate) is used to reverse severe vitamin K antagonist (warfarin, etc) bleeding. The dose is based on the patient’s INR and body weight.
INR
Dose in units
< 2.0
NA
2.0 to 3.99
MIN((25 * (weight in kg)), 2500)
4.0 to 6.0
MIN((35 * (weight in kg)), 3500)
> 6.0
MIN((50 * (weight in kg)), 5000)
where:
• The maximum dose is reached when the body weight is 100 kilograms. The maximum dose should not be exceeded even if the body weight is higher.
infusion rate =
= MIN(8.4, (0.12 * (weight in kg))) in mL per min
The maximum infusion rate is reached at 70 kilograms.
To read more or access our algorithms and calculators, please log in or register.
