Gilbert's syndrome and Crigler-Najjar Disease (CND) Type II can be distinguished from Crigler-Najjar Disease Type I by a number of tests.
(1) amount of bilirubin monoglucuronide in bile
(2) effect of phenobarbital on serum unconjugated and total bilirubin
(3) hepatic UDP-glucuronosyl transferase activity
Gilbert's or CND Type II
CND Type I
bilirubin monoglucuronide in bile
absent or very low
effect of phenobarbital
decrease in unconjugated and total bilirubin
hepatic UDP-glucuronosyl transferase activity
below normal but present
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Specialty: Gastroenterology, Genetics