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Distinguishing Gastrointestinal Bleeding from Swallowed Maternal Blood in a Neonate Using the Apt Test for Fetal Hemoglobin

Specialty:

Pedatrics

Objective:

ICD-10:

Description:

Apt and Downey developed a simple test for distinguishing maternal from fetal/neonatal blood in the stool of a newborn infant. Adult but not fetal hemoglobin is denaturated after exposure to alkali. This can help distinguish maternal blood swallowed during delivery from acute gastrointestinal bleeding in the neonate.

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