A patient treated with targeted therapy against CD20 may develop chronic and disseminated enteroviral infections:
Anti-CD20 targeted agents include rituximab and obinutuzumab.
Viruses: enterovirus, coxsackievirus, echovirus
Infections may include:
(1) myocarditis
(2) meningoencephalitis
(3) myositis
(4) hepatitis
(5) dermatomyositis-like syndrome
The diagnosis can be rapidly identified with PCR or other molecular technique.
Intravenous infusion of immune globulin (IVIg) is associated with a good therapeutic response.
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Specialty: Infectious Diseases, Gastroenterology, Pedatrics
