Temozolomide (brand name Temodar, Schering) is a chemotherapeutic agent used in the therapy of high grade astrocytoma. A series of capsules are dispensed to meet the prescribed daily dose. Proper dispensing is essential to prevent overdosage with excessive toxicity.
Dosage regimens for each cycle:
(1) initial: 150 mg per square meter BSA per day x 5 days
(2) subsequent: 200 mg per square meter BSA per day x 5 days
Capsule sizes:
(1) 5 mg
(2) 20 mg
(3) 100 mg
(4) 250 mg
|
Daily Dose in milligrams |
250 mg |
100 mg |
20 mg |
5 mg |
|---|---|---|---|---|
|
200 |
0 |
2 |
0 |
0 |
|
205 |
0 |
2 |
0 |
1 |
|
210 |
0 |
2 |
0 |
2 |
|
215 |
0 |
2 |
0 |
3 |
|
220 |
0 |
2 |
1 |
0 |
|
225 |
0 |
2 |
1 |
1 |
|
230 |
0 |
2 |
1 |
2 |
|
235 |
0 |
2 |
1 |
3 |
|
240 |
0 |
2 |
2 |
0 |
|
245 |
0 |
2 |
2 |
1 |
|
250 |
1 |
0 |
0 |
0 |
|
255 |
1 |
0 |
0 |
1 |
|
260 |
1 |
0 |
0 |
2 |
|
265 |
1 |
0 |
0 |
3 |
|
270 |
1 |
0 |
1 |
0 |
|
275 |
1 |
0 |
1 |
1 |
|
280 |
1 |
0 |
1 |
2 |
|
285 |
1 |
0 |
1 |
3 |
|
290 |
1 |
0 |
2 |
0 |
|
295 |
1 |
0 |
2 |
1 |
|
300 |
0 |
3 |
0 |
0 |
|
305 |
0 |
3 |
0 |
1 |
|
310 |
0 |
3 |
0 |
2 |
|
315 |
0 |
3 |
0 |
3 |
|
320 |
0 |
3 |
1 |
0 |
|
325 |
0 |
3 |
1 |
1 |
|
330 |
1 |
0 |
4 |
0 |
|
335 |
1 |
0 |
4 |
1 |
|
340 |
0 |
3 |
2 |
0 |
|
345 |
0 |
3 |
2 |
1 |
|
350 |
1 |
1 |
0 |
0 |
|
355 |
1 |
1 |
0 |
1 |
|
360 |
1 |
1 |
0 |
2 |
|
365 |
1 |
1 |
0 |
3 |
|
370 |
1 |
1 |
1 |
0 |
|
375 |
1 |
1 |
1 |
1 |
|
380 |
1 |
1 |
1 |
2 |
|
385 |
1 |
1 |
1 |
3 |
|
390 |
1 |
1 |
2 |
0 |
|
395 |
1 |
1 |
2 |
1 |
|
400 |
0 |
4 |
0 |
0 |
|
405 |
0 |
4 |
0 |
1 |
|
410 |
0 |
4 |
0 |
2 |
|
415 |
0 |
4 |
0 |
3 |
|
420 |
0 |
4 |
1 |
0 |
|
425 |
0 |
4 |
1 |
1 |
|
430 |
1 |
1 |
4 |
0 |
|
435 |
0 |
4 |
1 |
3 |
|
440 |
0 |
4 |
2 |
0 |
|
445 |
0 |
4 |
2 |
1 |
|
450 |
1 |
2 |
0 |
0 |
|
455 |
1 |
2 |
0 |
1 |
|
460 |
1 |
2 |
0 |
2 |
|
465 |
1 |
2 |
0 |
3 |
|
470 |
1 |
2 |
1 |
0 |
|
475 |
1 |
2 |
1 |
1 |
|
480 |
1 |
2 |
1 |
2 |
|
485 |
1 |
2 |
1 |
3 |
|
490 |
1 |
2 |
2 |
0 |
|
495 |
1 |
2 |
2 |
1 |
|
500 |
2 |
0 |
0 |
0 |
check on total dose in mg dispensed =
= ((number 250 mg capsules) * 250) + ((number 100 mg capsules) * 100) + ((number 20 mg capsules) * 20) + ((number 5 mg capsules) * 5)
Specialty: Pharmacology, clinical
ICD-10: ,
