Damy et al reported a disease severity score for a patient with hereditary transthyretin amyloidosis (ATTRv). A group of findings relates to sensory findings. The authors are from multiple institutions in Europe.
Patient selection: hereditary transthyretin amyloidosis
Parameters for proprioception:
(1) Romberg test
(2) heel-to-toe walking test
Parameters for tactile sensation:
(1) loss of sensation
(2) numbness
(3) loss of light touch sensation in finger
(4) loss of light touch sensation in wrist
(5) loss of light touch sensation in toe
(6) loss of light touch sensation in ankle
(7) numbness in finger
(8) numbness in wrist
(9) numbness in toe
(10) numbness in ankle
|
Parameter
|
Finding
|
Points
|
|
Romberg test
|
normal
|
0
|
|
|
abnormal
|
0.18
|
|
heel-to-toe walking test
|
normal
|
0
|
|
|
neuropathic gait
|
0.19
|
|
loss of sensation
|
no
|
0
|
|
|
yes
|
0.38
|
|
numbness
|
no
|
0
|
|
|
yes
|
0.22
|
|
loss of light touch, finger
|
no
|
0
|
|
|
yes
|
0.31
|
|
loss of light touch, wrist
|
no
|
0
|
|
|
yes
|
0.38
|
|
loss of light touch, toe
|
no
|
0
|
|
|
yes
|
0.28
|
|
loss of light touch, ankle
|
no
|
0
|
|
|
yes
|
0.33
|
|
numbness, finger
|
normal
|
0
|
|
|
reduced
|
0.24
|
|
numbness, wrist
|
normal
|
0
|
|
|
reduced
|
0.27
|
|
numbness, toe
|
normal
|
0
|
|
|
reduced
|
0.20
|
|
numbness, ankle
|
normal
|
0
|
|
|
reduced
|
0.22
|
subscore for proprioception =
= SUM(points for 2 parameter)
subscore for tactile sensation =
= SUM(points for the 10 parameters)
Interpretation:
• minimum subsores: 0
• maximum subscore for proprioception: 0.37
• maximum subscore for tactile sensation: 2.83
