The All Japan TAFRO Syndroe Research Group reported a classification for the severity of TAFRO Syndrome, with initial criteria in 2015 and an update in 2019.
Patient selection: TAFRO syndrome
Parameters:
(1) anasarca (pleural effusion on imaging, ascites on imaging, pitting edema)
(2) thrombocytopenia (platelet count per µL)
(3) fever and/or inflammation (body temperature in °C or serum CRP in mg/dL)
(4) renal insufficiency (GFR)
Parameter |
Finding |
Points |
pleural effusion |
absent |
0 |
|
present |
1 |
ascites |
absent |
0 |
|
present |
1 |
pitting edema |
absent |
0 |
|
present |
1 |
thrombocytopenia |
>= 100,000 per µL |
0 |
|
50,000 to 99,999 |
1 |
|
10,000 to 49,999 |
2 |
|
< 10,000 per µL |
3 |
fever and/or inflammation |
temperature < 37.5°C |
0 |
|
temperature 37.5 to 37.9°C |
1 |
|
temperature 38 to 38.9°C |
2 |
|
temperature >= 39°C |
3 |
|
serum CRP < 2 mg/dL |
0 |
|
serum CRP 2 to 9.9 mg/dL |
1 |
|
serum CRP 10 to 19.9 mg/dL |
2 |
|
serum CRP >= 20 mg/dL |
3 |
renal insufficiency |
GFR >= 60 mL per min per 1.73 sq m |
0 |
|
GFR 30 to 59 |
1 |
|
GFR 15 to 29 |
2 |
|
GFR < 15 mL per min per 1.73 sq m |
3 |
total score =
= SUM(points for all of the parameters)
Interpretation:
• minimum score: 0
• maximum score: 12
Total Score |
Severity |
Grade |
0 to 4 |
mild |
1 |
5 or 6 |
moderate |
2 |
7 or 8 |
slightly severe |
3 |
9 or 10 |
severe |
4 |
11 or 12 |
very severe |
5 |
Specialty: Hematology Oncology