Marti et al developed a discriminant function to evaluate patients with idiopathic dilated cardiomyopathy. This can help identify patients who may be candidates for cardiac transplantation. The authors are from Hospital de le Santa Creu I Sant Pau (Barcelona), Institut Municipal d'Investigacio Medica (Barcelona), and the Allegheny University of Health Services in Philadelphia.

Patient selection (page 746):

(1) Idiopathic dilated cardiomyopathy diagnosed by echocardiography, with left ventricular dilatation and reduced left ventricular ejection fraction, in the absence of angiographic evidence of coronary artery disease.

(2) All patients had >= 1 episode of heart failure requiring hospital admission.

(3) Heart failure was NYHA functional class III or IV and refractory to medical therapy.

(4) About a fifth had alcoholic cardiomyopathy.



(1) mean right atrial pressure in mm Hg

(2) cardiac index in liters per minute per square meter BSA

(3) New York Heart Association Functional Class (NYHA) from 1 to 4


discriminant score =

= (0.100072 * (mean right atrial pressure)) - (0.66007 * (cardiac index)) + (0.38627 * (NYHA functional class)) + 0.12005



• Patients who survived had a mean discriminant score of (-0.46) +/- 1.0 (range for +/- 2 SD is (-2.46) to 1.54; value for mean + 1 SD is 0.54).

• Patients who died had a mean discriminant score of 1.42 +/- 0.92 (range for +/- 2 SD is (-0.42) to 3.26; value for mean minus 1 SD is 0.50).


Using this information, one possible interpretation table would be:


Discriminant Score


< (-0.42)


<= 0.50

probably alive

> 0.50

probably died

> 1.54



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