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Discriminant Functions of Eldibany et al for Diagnosing Microcytic Anemias

Purpose: To use a patient's red blood cell indices to aid in the diagnosis of microcytic anemia.

Description

A patient's red cell indices can be used in discriminant functions to aid in the diagnosis of microcytic anemia.


Red cell indices used:

(1) MCH in picograms

(2) MCV in femtoliters

(3) RBC count as 10^12/L

(4) RDW in percent

 

Coefficient

Normal

Alpha-
thalassemia

Beta-
thalassemia

Iron-deficiency anemia

MCH

6.388

4.613

4.852

3.249

MCV

3.981

3.616

3.277

4.115

RBC

24.101

24.314

23.865

20.607

RDW

9.936

10.164

10.011

10.842

constant

-396.710

-325.996

-303.446

-325.140

 

 

group classification function =

= ((coefficient for MCH) * (MCH in picograms)) + ((coefficient for MCV) * (MCV in femtoliters)) + ((coefficient for RBC) * (RBC in 10^12/L)) + ((coefficient for RDW) * (RDW in percent)) + (constant)

 

Interpretation:

• The group with the highest classification function result is the probable diagnosis.

 

NOTE: When the data on page 681 is entered into the equations, my results are about 55-57 points lower than that given in the paper (260.72 vs 315.003, etc.)


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Specialty

Objective

ICD-10