Gangat et al modified the Dynamic International Prognostic Scoring System (DIPSS, see previous section) with the addition of additional parameters. This can improve its performance. The authors are from the Mayo Clinic, University of Pavia, and the University of Barcelona.
Parameters:
(1) risk groups from the DIPSS
(2) karyotype
(3) platelet count
(4) dependency on red blood cell transfusion
|
Parameter |
Finding |
Points |
|
DIPSS risk group |
low |
0 |
|
|
intermediate-1 |
1 |
|
|
intermediate-2 |
2 |
|
|
high |
3 |
|
karyotype |
favorable |
0 |
|
|
unfavorable |
1 |
|
platelet count |
>= 100,000 per µL |
0 |
|
|
< 100,000 per µL |
1 |
|
blood transfusion |
not dependent |
0 |
|
|
dependent |
1 |
where:
• The unfavorable karyotypes are those reported by Caramazza et al (see next section).
total DIPSS plus score =
= SUM(points for all 4 parameters)
Interpretation:
• minimum score: 0
• maximum score: 6
• The higher the score the worse the prognosis.
|
DIPSS Plus |
Risk Group |
10 Year Survival |
|
0 |
low |
63% |
|
1 |
intermediate-1 |
29% |
|
2 or 3 |
intermediate-2 |
10% |
|
4, 5 or 6 |
high |
3.6% |
estimated from Figure 2, page 395
Specialty: Hematology Oncology
ICD-10: ,
