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Reversing Digoxin Overdosage with Fab Antibody Fragments

Purpose:

To calculate the amount of anti-digoxin Fab fragments to give in a patient with digoxin toxicity.

Specialty:

Toxicology
Emergency Medicine
Critical Care
Cardiology

Objective:

options, adverse effects

ICD-10:

T46.0

Description:

Each 40 mg vial of digoxin-specific Fab fragments neutralizes about 0.6 mg of digoxin. The vial is reconstituted with 4 mL of sterile water. After mixing, the contents of the vials can be diluted in 0.9% sodium chloride to allow for more convenient infusion. The solution should be infused in 15-30 minutes. A 0.22 micron filter should be used to exclude undissolved immunoglobulin aggregates.

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