Scleromyxedema may occasionally resemble scleroderma.
Features shared by scleromyxedema and scleroderma:
(1) Raynaud's phenomenon
(2) sclerodactyly
(3) esophageal dysmotility
(4) myopathy
(5) telangiectasia
(6) skin thickening
Features useful for recognizing scleromyxedema:
(1) numerous skin papules
(2) monoclonal gammopathy
(3) dermal mucinous material in skin biopsy
(4) skin movable over subcutaneous tissues with deep skin folds ("Shar-Pei sign")
(5) leonine facies and deposits in the external ear
Situations where the diagnosis may be more difficult:
(1) papular eruption inapparent
(2) failure to biopsy
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Specialty: Dermatology, Immunology/Rheumatology
