A number of conditions may cause skin fibrosis that may mimic scleroderma.
Conditions that may mimic scleroderma:
(1) eosinophilic fasciitis
(2) graft-vs-host disease (GVHD)
(3) lichen sclerosus et atrophicus
(4) POEMS syndrome (with monoclonal gammopathy)
(5) overlap syndromes (with dermatomyositis, SLE or other autoimmune disorder)
(6) scleromyxedema
(7) systemic amyloidosis
(8) nephrogenic systemic fibrosis (nephrogenic fibrosing dermatopathy)
(9) scleroderma adultorum
(10) diabetes stiff skin syndrome
(11) lipodermatosclerosis
(12) progeroid disorders
(13) stiff skin syndrome
(14) phenylketonuria
(15) porphyia cutanea tarda
(16) myxedema (hypothyroidism)
(17) polyvinyl chloride exposure
(18) organic solvent exposure
(19) silica exposure
(20) epoxy resin exposure
(21) bleomycin therapy
(22) pentasocine therapy
(23) carbidopa therapy
(24) L-tryptophan exposure (eosinophilia myalgia syndrome)
(25) toxic-oil syndrome (aniline-denatured rapeseed oil)
(26) post-radiation fibrosis
Purpose: To identify a condition that may mimic scleroderma.
Specialty: Immunology/Rheumatology
Objective: differential diagnosis and mimics, red flags
ICD-10: L90, L91, L92, M34,