An HIV-positive patient may develop thrombocytopenia in a number of ways.
bone marrow suppression related to advanced HIV disease (HIV-associated thrombocytopenia)
AIDS with exclusion of other conditions, remits on therapy with zidovudine
disseminated infection affecting the bone marrow (histoplasmosis, tuberculosis, etc)
positive bone marrow cultures; organisms seen on bone marrow biopsy
malignant lymphoma or other tumor involving the bone marrow
bone marrow involvement
immune thrombocytopenic purpura (ITP)
temporal appearance related to drug therapy; remits on stopping drug
microangiopathic hemolytic anemia; abnormality ADAMTS13; preceding infection with E. coli 0157
disseminated intravascular coagulation (DIC)
positive fibrin split products, hypofibrinogenemia
aplastic or hypoplastic marrow
absent or reduced megakaryocytes in bone marrow biopsy
A patient may have more than one of these conditions.
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Specialty: Hematology Oncology, Clinical Laboratory, Infectious Diseases