Differential Diagnosis of Sinonasal Sarcoidosis

Sinonasal sarcoidosis is a diagnosis of exclusion.

Differential diagnosis:

(1) infection

(2) autoimmune vasculitis

(3) drug abuse

(4) other

Condition	Workup
tuberculosis, leprosy or other mycobacterial infection	history, negative AFB stain, culture, chest X-ray, PPD or QuantiFERON
fungal infection	history, fungal stain, culture, serum antibody
syphilis	serologic testing
Wegener’s granulomatosis	serum ANCA, vasculitis
Churg-Strauss	asthma, eosinophilia, serum IgE
other vasculitis	serum ANCA, serum ANA, vasculiits
cocaine or other inhaled drug of abuse	history, random drug testing
iatrogenic	history of surgery
trauma	history of facial trauma

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