Ross et al listed hematologic abnormalities that can be seen in a patient with a systemic vasculitis. The authors are from Norfolk and Norwich Hospital in England.
NOTE: The original table is index by category (disease-related, treatment-related, sepsis-related). The current table is indexed by the hematologic feature.
(7) pancytopenia (anemia + leukopenia + thrombocytopenia)
anemia of chronic disease
disease present for several years, exclusion of other causes
hemorrhage, with blood loss anemia
microangiopathic hemolytic anemia
schistocytes, active vasculitis
clinical signs of sepsis, positive culture
Wegener's granulomatosis or Churg Strauss
allergic reaction to drugs
schistocytes, fibrin split products
systemic CMV infection
immunosuppression, positive viral culture, inclusions in biopsy
hypoplastic or aplastic marrow
• Masking can occur when opposite effects (thrombocytosis and thrombocytopenia, leukocytosis and leukopenia) occur at the same time.
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Specialty: Hematology Oncology, Clinical Laboratory, Immunology/Rheumatology