Recurrent or chronic ulceration of the conjunctiva can be seen in a number of conditions.
Infectious causes of recurrent or chronic conjunctival ulcerations:
(1) Herpes simplex virus (HSV)
(2) fungal infection
(3) syphilis
(4) tuberculosis
(5) Pseudomonas species
(6) Hemophilus ducreyi (chancroid, soft chancre)
Autoimmune causes of recurrent or chronic conjunctival ulcerations:
(1) Behcet’s disease
(2) Crohn’s disease
(3) Wegener’s granulomatosis
(4) mucous membrane pemphigoid
Drug causing recurrent or chronic conjunctival ulcerations:
(1) iron compounds (ferrous salt, iron dextran)
(2) amphotericin B
(3) salicylate including aspirin
(4) phenytoin
(5) allopurinol
(6) fluorouracil
(7) floxuridine
(8) gentamicin
