The bone marrow may contain pseudo-Gaucher cells in certain conditions. These cells resemble Gaucher cells but do not contain the same tubular inclusions.
A pseudo-Gaucher cells:
(1) is a histiocyte
(2) has a "wrinkled tissue paper appearance" due to a needle-like inclusions within an expanded cytoplasm
(3) has an eccentric, lobulated nucleus
Conditions associated with pseudo-Gaucher cells:
(1) thalassemia
(2) sickle cell anemia
(3) chronic myelogenous leukemia
(4) myeloma or MGUS (monoclonal gammopathy of undetermined significance)
(5) Hodgkin's disease
(6) non-Hodgkin's malignant lymphoma
(7) myelodysplastic syndrome
(8) ALL
(9) disseminated mycobacteria infection in AIDS
Differential diagnosis:
(1) Gaucher cells (true Gaucher's disease)
(2) sea blue histiocytes
(3) other cytoplasmic inclusions
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