The bone marrow may contain pseudo-Gaucher cells in certain conditions. These cells resemble Gaucher cells but do not contain the same tubular inclusions.


A pseudo-Gaucher cells:

(1) is a histiocyte

(2) has a "wrinkled tissue paper appearance" due to a needle-like inclusions within an expanded cytoplasm

(3) has an eccentric, lobulated nucleus


Conditions associated with pseudo-Gaucher cells:

(1) thalassemia

(2) sickle cell anemia

(3) chronic myelogenous leukemia

(4) myeloma or MGUS (monoclonal gammopathy of undetermined significance)

(5) Hodgkin's disease

(6) non-Hodgkin's malignant lymphoma

(7) myelodysplastic syndrome

(8) ALL

(9) disseminated mycobacteria infection in AIDS


Differential diagnosis:

(1) Gaucher cells (true Gaucher's disease)

(2) sea blue histiocytes

(3) other cytoplasmic inclusions


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