A low absolute neutrophil count can occur in a neonate for a number of reasons.
The diagnosis of neutropenia should be based on the absolute neutrophil count relative to a reference range based on age, gender and race.
(1) sepsis or other bacterial infection
(2) maternal hypertension
(3) neonatal alloimmune neutropenia (NAIN)
(4) congenital viral infection
(5) prematurity (reduced production)
Less common causes:
(1) Kostmann Syndrome (infantile genetic agranulocytosis)
(2) other congenital neutropenia
(3) twin-twin transfusion
(5) neonatal leukemia
(1) artifact due to sample collection or handling
(2) racial variation (Black lower than White)
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Specialty: Hematology Oncology, Clinical Laboratory