A number of conditions can result in hypotelorism.
Hypotelorism is a lower than normal distance between the bony orbits and between the pupils (interpupillary distance.
Conditions associated with hypotelorism include:
(1) 18p- syndrome
(2) 5p- D syndrome
(3) cebocephalia
(4) Cockayne syndrome
(5) Coffin-Siris syndrome
(6) ethmocephalus
(7) familial hypotelorism
(8) fetal hydantoin syndrome
(9) frontonasal dysplasia syndrome (median cleft lip)
(10) Hallerman-Streiff syndrome
(11) holoprosencephaly (arrhinencephaly)
(12) Meckel-Gruber syndrome
(13) medium philtrum-premaxilla anlarge
(14) oculo-dental-digital dysplasia
(15) oculoauriculovertebral dysplasia (Goldenhar syndrome)
(16) Opitz trigonocephaly sydrome
(17) phenylketonuria (in fetus born to affected mother)
(18) Ring syndrome
(19) Schilbach-Rott syndrome
(20) Trisomy 13 (Patau syndrome)
(21) Trisomy 20p syndrome
(22) Trisomy 21 (Down syndrome)
(23) Turner syndrome
(24) Williams syndrome
(25) Wolf syndrome
