Hyperphagia may be due to a range of conditions.
Genetic causes of hyperphagia include:
(1) Prader-Will Syndrome (monosomy 1p36)
(2) 22q11.2 deletion
(3) Trisomy 21
(4) Bardet-Biedl
(5) WAGR syndrome 11p13
(6) polymorphism in genes affecting the hypothalamic weight-regulating pathways
Drug or chemical related:
(1) triggered by drug therapy (SGLT-2 inhibitor, topiramate, fluoxetine, other)
(2) associated with withdrawal (nicotine, other)
Neuropsychiatric:
(1) CNS lesions involving hypothalamus or thalamus
(2) other conditions affecting the hypothalamus or thalamus (radiation, trauma)
(3) psychiatric (neurosis, impulsivity, dementia)
(4) behavioral (food as reward or comfort)
Premenstrual or pregnancy-associated.
Polycystic ovary syndrome
Disorders affecting release or response to signalling compounds (leptin, ghrelin)
Physiologic (extreme exercise or exertion)
Most forms of hyperphagia present with obesity. One exception is physiologic due to extreme exertion.
