Hemorrhagic disease of the newborn (HDNB) needs to be distinguished from other causes of neonatal or infantile bleeding.


Hereditary coagulation factor defects:

(1) hemophilia A or B (Factor 8 or 9 deficiency)

(2) von Willebrand’s disease


Acquired coagulation factor defects:

(1) coumarin or heparin exposure (accidental, intentional)

(2) liver disease



(1) hereditary platelet defects

(2) immune thrombocytopenic purpura (ITP)

(3) neonatal isoimmune thrombocytopenia

(4) congenital leukemia

(5) bone marrow hypoplasia or aplasia



(1) disseminated intravascular coagulation (DIC)

(2) infection or sepsis


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