A number of conditions may be associated with deep-set eyes.

Conditions associated with deeply set eyes include:

(1) Cockayne syndrome (associated with optic hypoplasia and cachexia)

(2) Craniocarpotarsal syndrome (Freeman-Sheldon syndrome)

(3) familial

(4) Marfan's syndrome

(5) mesodermal dysmorphodystrophy (Weill-Machesani syndrome)

(6) oculocerebrorenal syndrome )Lowe syndrome)

(7) pyknodysostosis

(8) blepharophimosis with myopathy


In severe cachexia there is less retro-orbital fat, which can result in the eyes appearing "sunken."

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