Clinical hypoaldosteronism represents a constellation of clinical and laboratory features that may be caused by a variety of disorders.
Clinical features of hypoaldosteronism:
(1) renal salt-wasting with dehydration
(3) metabolic acidosis
Aldosterone receptor expression can be determined by testing peripheral mononuclear cells with competitive RT-PCR (Heering et al).
pseudohypoaldosteronism (with decreased receptors)
• Mineralocorticoid resistance may be due to a qualitative defect in the receptor, receptor blockade (for example by autoantibody), drug interference or other cause.
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Specialty: Endocrinology, Clinical Laboratory, Nephrology, Cardiology