A number of disorders may occur in the orbit of a patient with systemic lupus erythematosus (SLE).

Orbital pathology that can occur in SLE:

(1) periorbital edema

(2) ocular myositis

(3) inflammatory pseudotumor

(4) orbital apex syndrome

(5) orbital ischemia/infarction

(6) panniculitis

(7) acquired Brown's syndrome


MRI and other imaging studies can help to localize the process but the diagnosis may require a biopsy.


Differential diagnosis:

(1) opportunistic infection

(2) tumors unrelated to SLE

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