Erythroderma (“red baby”) may be presenting complaint for a variety of disorders affecting an infant or young child..


Differential diagnosis:

(1) infection

(1a) Staphylococcal scalded skin syndrome

(1b) toxic shock syndrome (Staphylococcus aureus or Streptococcus pyogenes)

(1c) Candidiasis

(2) ichythyosis

(2a) Netherton’s syndrome

(2b) ichthyosiform erythoderma, bullous or nonbullous

(2c) Contradi-Hunermann syndrome

(3) disorder of biotin metabolism

(3a) holocarboxylase synthetase deficiency

(3b) biotinidase deficiency

(4) drug reaction, often to antibiotics

(5) dermatologic disorders

(5a) seborrheic dermatitis

(5b) atopic dermatitis

(5c) pityriasis rubra pilaris

(5d) psoriasis

(6) immunodeficiency

(6a) Omenn’s syndrome (combined immunodeficiency)

(6b) severe combined immunodeficiency (SCID)

(7) graft-vs-host disease

(8) systemic mastocytosis

(9) essential fatty acid deficiency secondary to malabsorption

(10) secretory IgA deficiency

(11) Wiskott-Aldrich syndrome


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