Macrocytic anemia is associated with an elevated mean cell volume (MCV).
Macrocytic anemia with hypersegmented neutrophils is termed megaloblastic.
Common causes of macrocytic anemia:
(1) vitamin B12 deficiency
(2) folate deficiency
(3) myelodysplasia
(4) drug-induced megaloblastosis
Less common causes:
(1) congenital dyserythropoietic anemia
(2) thiamine-dependent megaloblastic anemia
(3) ethanol in high doses
(4) hypothyroidism
(5) reticulocytosis (including immune hemolytic anemia)
(6) liver disease
(7) cold agglutinin disease
(8) aplastic anemia
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Specialty: Hematology Oncology
