DIC Score of Yu et al

 

Parameters for score:

(1) clinical setting

(2) thrombohemorrhagic events

(3) screening coagulation tests (prothrombin time, activated partial thromboplastin time, thrombin time)

(4) platelet count

(5) fibrinogen

(6) fibrin degradation products (FDP)

(7) D-dimer

(8) antithrombin III levels

 

Parameter	Finding	Points
clinical setting	absent	0
	present	1
thrombohemorrhagic events	absent	0
	present	1
coagulation screening tests	PT, PTT and TT normal	0
	PT, or PTT, or TT prolonged	1
platelet count	>= 130,000 per µL	0
	< 130,000 per µL (thrombocytopenia)	1
fibrinogen level	>= 150 mg/dL	0
	< 150 mg/dL (decreased)	1
FDP	<= 10 µg/mL	0
	> 10 µg/mL (elevated)	1
D-dimer	<= 0.25 µg/mL	0
	> 0.25 µg/mL (elevated)	1
antithrombin III levels	>= 75% of normal	0
	< 75% (low)	1

 

Clinical setting:

(1) obstetric accidents (amniotic fluid embolism, placental abruption, retained fetus syndrome, eclampsia, abortion)

(2) intravascular hemolysis (hemolytic transfusion reaction, minor hemolysis, massive transfusions)

(3) septicemia

(4) viremias

(5) metastatic malignancy

(6) leukemia (acute promyelocytic, acute myelomonocytic)

(7) burns

(8) crush injuries and tissue necrosis

(9) trauma

(10) acute liver disease

(11) prosthetic devices (Leveen shunt, Denver shunt, aortic balloon assist device)

(12) vascular disorders

(13) disorders associated with low-grade DIC (cardiovascular disease, autoimmune disease, renal vascular disorders, hematologic disorders, inflammatory disorders)

 

Thrombohemorrhagic events: one or more of the following:

(1) petechiae

(2) purpura

(3) hemorrhagic bullae

(4) acral cyanosis

(5) frank gangrene

(6) bleeding or oozing from wounds, incision sites, venipuncture sites, etc

(7) large subcutaneous hematomas

(8) deep tissue bleeding

(9) thrombosis

 

DIC score =

= SUM(points for all 8 parameters)

 

Interpretation:

• minimum score: 0

• maximum score: 8

• A score >= 5 is needed for the diagnosis of DIC.