Primary Thrombocythemia Scores - Medical Diagnostic Tool

Dudley et al developed a simple scoring system for diagnosing primary (essential) thrombocythemia.

Patient selection: Patients had a platelet count > 600,000 per µL

Finding	Points
splenic enlargement on scan	2
unstimulated BFU-E derived colonies present	2
elevated platelet ATP/ADP ratio (> 4 standard deviations above mean)	1
elevated platelet distribution width (> 2 standard deviations above mean)	1
clinical ischemia present	1

where:

• BFU-E indicates erythroid colony forming units from peripheral blood

• The ATP/ADP ratio indicates the ratio of platelet ATP to ADP (platelet nucleotide ratio).

score =

= SUM(points for 5 findings)

Interpretation:

• A score >= 3 indicates primary thrombocythemia.

• A score < 3 indicates secondary or reactive thrombocytosis.

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Diagnostic Scoring System for Primary Thrombocythemia of Dudley et al