Valent et al reported criteria for the diagnosis of basophilic leukemia. The authors are from multiple institutions in Europe and the United States.

Criteria for basophilic leukemia:

(1) hyperbasophilia (absolute basophil count >= 1,000 per µL) with clonal myeloid disease

(2) percent basophils in the differential count >= 40%

(3) presence of myeloblasts and metachromatic blasts (>= 20% in acute, < 20% in chronic)



(1) CML (with Ph-chromosome or BCR-ABL1)

(2) myeloproliferative neoplasm (MPN-baso)

(3) myelodysplasia (MDS-baso)

(4) acute myeloid leukemia (AML-baso)

(5) T-cell neoplasm


Basophilic leukemia is diagnosed when other causes of hyperbasophilia have been excluded.

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