Labenne et al developed a score for predicting early-onset neonatal infection (EONI) in a preterm infant. This can help to distinguish an infant who is infected from one who is not. The authors are from Centre Hospitalier Universitaire de Dijon, Centre d'Investigation Clinique and Faculte des Sciences Gabriel in France.
Patient selection: preterm infant in the neonatal intensive care unit (NICU)
Parameters:
(1) clinical signs and symptoms
(2) blood or CSF culture
(3) serum CRP concentration
(4) superficial placental culture
(5) alternative explanation
(6) recovery without antibiotics
Clinical signs and symptoms of sepsis:
(1) fever OR hypothermia
(2) respiratory distress
(3) grunting
(4) apnea
(5) bradycardia OR tachycardia
(6) pallor
(7) poor capillary refill
(8) hypotension
(9) hypotonia
(10) lethargy
|
Paraemeters |
Definite EONI |
Possible EONI |
|
clinical signs and symptoms |
present |
present |
|
blood or CSF culture |
positive |
NA |
|
serum CRP |
NA |
> 10 mg/L |
|
superficial placental culture |
NA |
positive |
|
alternative explanation |
NA |
none |
|
recovery without antibiotics |
NA |
NA |
|
Parameters |
EONI Probably Excluded |
EONI Probably Excluded |
|
clinical signs and symptoms |
NA |
NA |
|
blood or CSF culture |
negative |
negative |
|
serum CRP |
<= 10 mg/L |
> 10 mg/L |
|
superficial placental culture |
positive |
NA |
|
alternative explanation |
NA |
present |
|
recovery without antibiotics |
NA |
NA |
|
Parameters |
EONI Excluded |
EONI Excluded |
|
clinical signs and symptoms |
NA |
present |
|
blood or CSF culture |
negative |
negative |
|
serum CRP |
<= 10 mg/L |
NA |
|
superficial placental culture |
negative |
NA |
|
alternative explanation |
NA |
NA |
|
recovery without antibiotics |
NA |
Yes |
Specialty: Pedatrics, Infectious Diseases
ICD-10: ,
