Harden et al reported proposed diagnostic criteria for the Complex Regional Pain Syndrome (CRPS). The authors are from Northwestern University, Vanderbilt Univeristy, the Cleveland Clinic and the Mayo Clinic in Rochester.


Definition of CRPS:

(1) array of painful conditions that shows a variable progression over time

(2) pain is regional and not in a specific nerve territory or dermatome

(3) pain may be spontaneous and/or evoked

(4) evoked pain is disproportionate in time and/or degree to the inciting event

(5) pain shows a distal predominance with abnormal sensory, vasomotor, sudomotor, motor or trophic findings


Criteria - all 4 of the following:

(1) continuing pain, out of proportion to any inciting event

(2) reports >= 1 symptom in >= 3 categories (below)

(3) presence of >= 1 sign in >= 2 categories (below) at the the time of evaluation

(4) exclusion of alternative diagnosis that can explain the findings better


Item 1

Item 2

Item 3


hyperesthesia, hyperalgesia (to pinprick)




temperature asymmetry (> 1°C)

skin color changes

skin color asymmetry

sudomotor, edema


sweating changes

sweating asymmetry

motor, trophic

decreased range of motion

motor dysfunction (weakness, tremor, dystonia)

trophic changes in skin, nails and/or hair



• Allodynia may be in response to light touch, temperature sensation, deep somatic pressure, and/or joint movement.


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