Major criteria:
(1) temperature >= 99.0 °F (37.2°C)
(2) severe rigidity or tremors (extrapyramidal signs or EPS)
Minor criteria:
(1) tachycardia (>= 100 beats per minute)
(2) hypertension (>= 150/100 mm Hg)
(3) sweating (diaphoresis)
(4) leukocytosis (> 10,800 per µL)
(5) confusion or altered consciousness
(6) incontinence
(7) elevated serum CK (> 83 IU/L)
High probability of NMS:
(1) 2 major criteria AND 3 minor criteria within 48 hours
Probable NMS - one of the following:
(1) 2 major criteria AND >= 1 minor criteria within 48 hours
(2) 1 major criteria AND >= 3 minor criteria within 48 hours
