A neonate with Persistent Pulmonary Hypertension of the Newborn (PPHN) presents with a number of clinical findings.



(1) severe postnatal hypoxemia

(2) severe respiratory failure require intubation and mechanical ventilation


Evaluation shows:

(1) a persistent elevation of pulmonary vascular resistance

(2) a persistent elevation in right ventricular pressure

(3) a right-to-left shunt through a patent foramen ovale and/or a patent ductus arteriosus

(4) an elevated serum BNP


Exclusion: The changes are not due to another congenital anomaly.


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